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4-Methylpyridin-2-amine

4-Methylpyridin-2-amine structure

CAS No.: 695-34-1

Chemical Name:: 4-Methylpyridin-2-amine

Synonyms: 2-AMINO-4-METHYLPYRIDINE;2-AMINO-4-PICOLINE;Aminopicoline;w45;W 45;4M2AP;ra1226;RA 1226;NSC 1490;NSC 6972

CBNumber:: CB9854129

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00149166

MOL File:: 695-34-1.mol

MSDS File:: SDS

Last updated:2024-05-10 09:59:16

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4-Methylpyridin-2-amine Properties

Melting point	96-99 °C (lit.)
Boiling point	230 °C (lit.)
Density	1.0275 (estimate)
vapor pressure	3.71Pa at 25℃
refractive index	1.5560 (estimate)
Flash point	118 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMF: freely soluble
form	Flakes
pka	pK1: 7.48(+1) (25°C)
color	Slightly yellow to beige or brown
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
Merck	14,466
BRN	107066
LogP	0.56-1.08
CAS DataBase Reference	695-34-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	394N1Z644H
NIST Chemistry Reference	2-Pyridinamine, 4-methyl-(695-34-1)
EPA Substance Registry System	2-Pyridinamine, 4-methyl- (695-34-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311+H331-H373

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P314

Hazard Codes

Risk Statements

45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25

Safety Statements

53-45-60-61-37/39-28A-26-36/37/39

RIDADR

UN 3086 6.1/PG 1

WGK Germany

RTECS

TJ5150000

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29333999

Toxicity

LD50 oral in rat: 200mg/kg

NFPA 704

	1
3		1

4-Methylpyridin-2-amine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	123080	2-Amino-4-methylpyridine 99%	695-34-1	100g	$59.9	2024-03-01	Buy
TCI Chemical	A0402	2-Amino-4-methylpyridine >98.0%(GC)(T)	695-34-1	25g	$65	2024-03-01	Buy
TCI Chemical	A0402	2-Amino-4-methylpyridine >98.0%(GC)(T)	695-34-1	500g	$390	2024-03-01	Buy
Alfa Aesar	A14177	2-Amino-4-methylpyridine, 98%	695-34-1	25g	$22.65	2024-03-01	Buy
Alfa Aesar	A14177	2-Amino-4-methylpyridine, 98%	695-34-1	100g	$32.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
123080	100g	$59.9	Buy
A0402	25g	$65	Buy
A0402	500g	$390	Buy
A14177	25g	$22.65	Buy
A14177	100g	$32.65	Buy

4-Methylpyridin-2-amine Chemical Properties,Uses,Production

Chemical Properties

Light yellow to brown flakes

Uses

2-Amino-4-methylpyridine has been used in the synthesis of 2-amino-4-methyl-pyridinium 2-hy-droxy-benzoate. It is potent inhibitor of NOS2 (iNOS) in vitro. It is used as pharmaceutical intermediate.

Uses

Intermediate, medicine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

General Description

2-Amino-4-methylpyridine acts as ligand and forms methoxo-bridged copper(II) complexes.

Biochem/physiol Actions

2-Amino-4-methylpyridine inhibits the activity of inducible NO synthase isolated from mouse RAW 264.7 cells in vitro.

Synthesis

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, the copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water, Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 4-Methylpyridin-2-amine as a yellow solid, the yield was 89.3percent. The crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 4-Methylpyridin-2-amine as a pale yellow solid.

Purification Methods

Crystallise it from EtOH or a 2:1 *benzene/acetone mixture, and dry it under vacuum as in the prevous entry. [Beilstein 22/9 V 325.]

4-Methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-3,5-DICHLORO-4-METHYLPYRIDINE 2-Amino-5-nitro-4-picoline 2-BROMO-3-IODO-ISONICOTINIC ACID 2-Amino-5-bromo-4-methylpyridine 2-ACETAMIDO-5-BROMOISONICOTINIC ACID

2-AMINO-ISONICOTINIC ACID HYDRAZIDE 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID 4-Pyridinecarbonyl chloride, 2-fluoro- (9CI) 2-AMINO-5-FLUORO-4-PICOLINE 2-Acetylamino-4-methylpyridine

2-Aminoisonicotinic acid Ethyl 2-Aminoisonicotinate 2-ACETAMIDO-5-NITRO-4-PICOLINE 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE (2-AMINO-PYRIDIN-4-YL)-METHANOL

2-Fluoroisonicotinic acid 2-ACETAMIDO-4-METHYL-5-BROMOPYRIDINE 2-CHLORO-3-HYDROXYISONICOTINIC ACID 2-Bromo-4-methylpyridine 2-Nitropyridine-4-carboxylic acid

2-ACETAMIDO-5-AMINO-4-PICOLINE

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4-Methylpyridin-2-amine Suppliers

Global( 639)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Terma Medicare India Pvt.,Ltd	+8613916485955	shivshanghai@yahoo.com	India	135	58
Jinan Dexinjia Bio&Tech Co., Ltd	+86-0531-82375893 +86-15553111391	sales@jndxj.com	China	1199	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5963	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	3001	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7019	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	283	58

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
Jinan Dexinjia Bio&Tech Co., Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hangzhou Cyanochem Co., Ltd.	58

View Lastest Price from 4-Methylpyridin-2-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	Aminopicoline 695-34-1	US $10.00 / kg	1kg	99.6%	100000	Ouhuang Engineering Materials (Hubei) Co., Ltd
2023-07-01	2-Amino-4-Methyl-Pyridin 695-34-1	US $5.00-2.00 / KG	1KG	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD
2023-03-03	4-Methylpyridin-2-amine 695-34-1	US $60.00 / kg	1kg	99%	100 tons	Hebei Duling International Trade Co. LTD

Aminopicoline
695-34-1
US $10.00 / kg
99.6%
Ouhuang Engineering Materials (Hubei) Co., Ltd

2-Amino-4-Methyl-Pyridin
695-34-1
US $5.00-2.00 / KG
99%
Hebei Guanlang Biotechnology Co,.LTD

4-Methylpyridin-2-amine
695-34-1
US $60.00 / kg
99%
Hebei Duling International Trade Co. LTD

4-Methylpyridin-2-amine Spectrum

4-Methylpyridin-2-amine(695-34-1)MS 4-Methylpyridin-2-amine(695-34-1)¹HNMR 4-Methylpyridin-2-amine(695-34-1)¹³CNMR 4-Methylpyridin-2-amine(695-34-1)IR1 4-Methylpyridin-2-amine(695-34-1)IR2 4-Methylpyridin-2-amine(695-34-1)IR3 4-Methylpyridin-2-amine(695-34-1)Raman

695-34-1(4-Methylpyridin-2-amine)Related Search:

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2-Amino-4,6-dimethylpyridine 2-Amino-5-nitro-4-picoline 2,3-Diamino-5-methylpyridine 5-Amino-3-methylpyridine 3-AMINO-2-METHOXY-6-PICOLINE

5-METHYLPYRIDIN-3-AMINE 4-AMINO-2-METHYLPYRIDINE (4-AMINO-2-PICOLINE),2-METHYLPYRIDIN-4-AMINE,4-Amino-2-methylpyridine ,97% 2-METHYLPYRIDIN-3-AMINE,3-AMINO-2-METHYLPYRIDINE (3-AMINO-2-PICOLINE),3-Amino-2-methylpyridine ,97% 2,6-DICHLORO-4-METHYLPYRIDIN-3-AMINE 2-Amino-3-ethyl-6-methylpyridine

6-Amino-5-methylpyridine-3-carbonitrile ,97%,5-Cyano-2-amino-3-methylpyridine 5-IODO-6-METHYLPYRIDIN-2-AMINE 5-Amino-2-chloro-3-picoline

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99.995% trace Metals basis w45raschig 4-METHYL-2-PYRIDYLAMINE 4-METHYLPYRIDIN-2-AMINE 4-METHYL-PYRIDIN-2-YLAMINE AKOS BBS-00004343 AKOS 91145 TIMTEC-BB SBB004354 OTAVA-BB BB7015122364 SODIUM DICHROMATE 2H2O SODIUM DICHROMATE-2-HYDRATE SODIUM DICHROMATE, HYDROUS SODIUM BICHROMATE DIHYDRATE AURORA 11319 2-Amino-4-Methylpyridine,Nevirapine 2-Pyridinamine,4-methyl-(9CI) 2-AMINO-4-METHYL PYRODINE 2-AMINO-4-METHYL PYRIDINE 4-METHYLPYRIDIN-2-YLAMINE 2-Amino-4-methylpyridine, 98+% NSC 1490 NSC 176165 NSC 6972 2-AMINO-4-METHYLPYRIDINE FOR SYNTHESIS 2-Amino-4-methylpyridine ,99% 2-Amino-4-picoline,98% 2-AMino-4-picoline, 98% 100GR 2-Amino-4-picoline, 4-Methylpyridin-2-amine 4M2AP 4-Methyl-2-aminopyridine 4-Methyl-2-pyridamine 4-methyl-2-pyridinamin 4-Methyl-2-pyridinamine 4-Picoline, 2-amino- alpha-Amino-gamma-picoline Ascensil component of Ascensil component of Askensil Methyl-4 amino-2-pyridine methyl-4amino-2-pyridine Pyridine, 2-amino-4-methyl- RA 1226 ra1226 VMI 20-4 W 45 W 45 Raschig Rifaximin EP Impurity A 2-amino-4-methyl-pyridin 2-amino-4-picolin 2-Amino-gamma-picoline 2-Aminop-4-picoline 2-Pyridinamine,4-methyl- w45 Rifaximin impurities Rifaximin Impurity 1 (Rifaximin EP Impurity A) 2-Amino-4-methylpyridine > 4-methylpyridine-2-amine 4-Methylpyridin-2-amine ISO 9001：2015 REACH 695-34-1 4-Methylpyridin-2-amine